As long as you aren't stopped by the Cave Fire Cleanup 101 might work heading north

If you are heading north from Say Los Angeles or San Diego to Oregon or Washington or Canada areas the best way north at present appears to be 101 along the coast where it stays a little warmer because of the pacific Ocean. I cannot guarantee 101 will stay open either so here is what Caltrans has to say at present. Because I-5 is now closed 25 miles south of Bakersfield and from Redding to at least Dunsmuir at present (however I would keep checking because it is likely that it will open northbound from Redding to Dunsmuir and points north by Noon to 3 or so before it might close up again this evening. So, you might make it through in a 3 or 4 hour window if it reopens northbound up from Redding.

Here is the latest on 101 in California from Caltrans:

Road Information

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This highway information is the latest reported as of Wednesday, November 27th, 2019 at 10:27 AM.

US 101

[IN THE SOUTHERN CALIFORNIA AREA]
NO TRAFFIC RESTRICTIONS ARE REPORTED FOR THIS AREA.

[IN THE CENTRAL CALIFORNIA AREA]
NO TRAFFIC RESTRICTIONS ARE REPORTED FOR THIS AREA.

[IN THE NORTHERN CALIFORNIA AREA]
1-WAY CONTROLLED TRAFFIC AT VARIOUS LOCATIONS FROM 11 MI SOUTH TO 10.4 MI SOUTH OF THE MENDOCINO/HUMBOLDT CO LINE - DUE TO A SLIP-OUT

1-WAY CONTROLLED TRAFFIC FROM 11 MI SOUTH TO 10.6 MI SOUTH OF CRESCENT CITY (DEL NORTE CO) 24 HRS A DAY THRU 1700 HRS ON MONDAY 8/31/20 - DUE TO CONSTRUCTION

end quote from:

https://roads.dot.ca.gov/