It's interesting that the Separation of Church and state made it to the U.S. between 5 and 18 million people died after Protestantism took hold in europe

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Estimates for deaths in European conflicts between Catholics and Protestants vary widely, but the

Thirty Years' War (1618–1648) alone is thought to have caused between 4.5 and 8 million deaths from battle, disease, and famine. Other major conflicts like the French Wars of Religion (1562–1598) resulted in an estimated 2 to 4 million deaths. Combined, the European Wars of Religion (16th–18th centuries) likely resulted in a total death toll between 5.5 and 18.5 million. 

Major conflicts and their estimated death tolls

• The Thirty Years' War (1618–1648):
  • Total estimated deaths: 4.5 to 8 million
  • Cause: Primarily fought in the Holy Roman Empire, it started as a conflict between Catholic and Protestant states but evolved into a more political war. Deaths resulted from combat, but heavily from famine and disease.
• French Wars of Religion (1562–1598):
  • Total estimated deaths: 2 to 4 million
  • Cause: A series of civil wars between French Catholics and Protestants (Huguenots).
• Eighty Years' War (1568–1648):
  • Total estimated deaths: 600,000 to 700,000
  • Cause: A conflict between Spain and its rebellious provinces in the Low Countries, which had a significant Protestant population.
• War of the Three Kingdoms (1639–1651):
  • Total estimated deaths: Approximately 868,000
  • Cause: A complex series of conflicts in Great Britain and Ireland that involved religious and political tensions, including the Irish Rebellion of 1641.
• Other events:
  • The St. Bartholomew's Day massacre in France (1572) resulted in the deaths of 5,000 to 30,000 Protestants.