I have been searching for something on this ever since I watched Fareed Zacharia's GPS today. A gentleman was on his program talking about how certain proteins awaken our stem cells after age 25 when they tend to go to sleep. However, because these experiments happened I believe in the 1920s they are difficult to find on an Internet that wasn't even begun to be constructed until the 1990s after Darpa did the initial research to prevent mass nuclear annihilation by creating a redundant computer network so the government would survive literally anything someplace.
So, I'm a little frustrated after hearing about the protein experiments conducted by Lundsford that are being validated today to benefit cancer patients and to lengthen human lives.
If you hear or have studied about this please publish this online so it is easier to find.
Found it, I put in search window: "proteins that awaken stem cells in humans" and found:
Protein that keeps blood stem cells healthy as they age identified by researchers
- Date:
- June 9, 2014
- Source:
- Mount Sinai Medical Center
- Summary:
- A protein may be the key to maintaining the health of aging blood stem cells, according to researchers. Human adults keep stem cell pools on hand in key tissues, including the blood. These stem cells can become replacement cells for those lost to wear and tear. But as the blood stem cells age, their ability to regenerate blood declines, potentially contributing to anemia and the risk of cancers like acute myeloid leukemia and immune deficiency. Whether this age-related decline in stem cell health is at the root of overall aging is unclear.
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FULL STORY
A protein may be the key to maintaining
the health of aging blood stem cells, according to work by researchers
at the Icahn School of Medicine at Mount Sinai recently published online
in Stem Cell Reports. Human adults keep stem cell pools on
hand in key tissues, including the blood. These stem cells can become
replacement cells for those lost to wear and tear. But as the blood stem
cells age, their ability to regenerate blood declines, potentially
contributing to anemia and the risk of cancers like acute myeloid
leukemia and immune deficiency. Whether this age-related decline in stem
cell health is at the root of overall aging is unclear.
The new Mount Sinai study reveals how loss of a protein called
Sirtuin1 (SIRT1) affects the ability of blood stem cells to regenerate
normally, at least in mouse models of human disease. This study has
shown that young blood stem cells that lack SIRT1 behave like old ones.
With use of advanced mouse models, she and her team found that blood
stem cells without adequate SIRT1 resembled aged and defective stem
cells, which are thought to be linked to development of malignancies.
"Our data shows that SIRT1 is a protein that is required to maintain the health of blood stem cells and supports the possibility that reduced function of this protein with age may compromise healthy aging," says Saghi Ghaffari, MD, PhD, Associate Professor of Developmental and Regenerative Biology at Mount Sinai's Black Family Stem Cell Institute, Icahn School of Medicine. "Further studies in the laboratory could improve are understanding between aging stem cells and disease."
Next for the team, which includes Pauline Rimmelé, PhD, is to investigate whether or not increasing SIRT1 levels in blood stem cells protects them from unhealthy aging or rejuvenates old blood stem cells. The investigators also plan to look at whether SIRT1 therapy could treat diseases already linked to aging, faulty blood stem cells.
They also believe that SIRT1 might be important to maintaining the health of other types of stem cells in the body, which may be linked to overall aging.
The notion that SIRT1 is a powerful regulator of aging has been highly debated, but its connection to the health of blood stem cells "is now clear," says Dr. Ghaffari. "Identifying regulators of stem cell aging is of major significance for public health because of their potential power to promote healthy aging and provide targets to combat diseases of aging," Dr. Ghaffari says.
"Our data shows that SIRT1 is a protein that is required to maintain the health of blood stem cells and supports the possibility that reduced function of this protein with age may compromise healthy aging," says Saghi Ghaffari, MD, PhD, Associate Professor of Developmental and Regenerative Biology at Mount Sinai's Black Family Stem Cell Institute, Icahn School of Medicine. "Further studies in the laboratory could improve are understanding between aging stem cells and disease."
Next for the team, which includes Pauline Rimmelé, PhD, is to investigate whether or not increasing SIRT1 levels in blood stem cells protects them from unhealthy aging or rejuvenates old blood stem cells. The investigators also plan to look at whether SIRT1 therapy could treat diseases already linked to aging, faulty blood stem cells.
They also believe that SIRT1 might be important to maintaining the health of other types of stem cells in the body, which may be linked to overall aging.
The notion that SIRT1 is a powerful regulator of aging has been highly debated, but its connection to the health of blood stem cells "is now clear," says Dr. Ghaffari. "Identifying regulators of stem cell aging is of major significance for public health because of their potential power to promote healthy aging and provide targets to combat diseases of aging," Dr. Ghaffari says.
Story Source:
The above post is reprinted from materials provided by Mount Sinai Medical Center. Note: Materials may be edited for content and length.
The above post is reprinted from materials provided by Mount Sinai Medical Center. Note: Materials may be edited for content and length.
Journal Reference:
- Pauline Rimmelé, Carolina L. Bigarella, Raymond Liang, Brigitte Izac, Rebeca Dieguez-Gonzalez, Gaetan Barbet, Michael Donovan, Carlo Brugnara, Julie M. Blander, David A. Sinclair, Saghi Ghaffari. Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells. Stem Cell Reports, 2014; DOI: 10.1016/j.stemcr.2014.04.015
Cite This Page:
Mount
Sinai Medical Center. "Protein that keeps blood stem cells healthy as
they age identified by researchers." ScienceDaily. ScienceDaily, 9 June
2014. .
end quote from:
http://www.sciencedaily.com/releases/2014/06/140609205023.htm
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