is plasma exchange rogue antibodies from Jugular vein a new procedure?

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Therapeutic plasma exchange (TPE)—used to remove harmful or "rogue" antibodies—is not a new procedure. It has been practiced for decades to treat autoimmune and neurological conditions. Accessing large veins like the internal jugular via a central venous catheter is also a standard, long-established method when peripheral veins are insufficient. 

How the Procedure Works

Blood separation: Blood is taken out and run through a specialized machine that separates cellular components from the plasma.
Removal: The plasma containing the pathogenic antibodies is discarded.
Replacement: Clean replacement fluid (like albumin or saline) is mixed with the blood cells and returned to the body. 

Use of the Jugular Vein

Central venous access: Large-volume blood flow is required rapidly during TPE.
Placement: Doctors frequently place a temporary or permanent central line catheter into the internal jugular vein in the neck because it provides direct, high-flow access to the heart. 

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  American College of Rheumatology

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  PubMed Central (PMC) (.gov)

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  Jul 12, 2025 — In the AMBAR trial, six sessions of weekly TPE with albumin replacement in patients with mild-to-moderate AD were associated with ...

  
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  www.uchealth.com

  Plasmapheresis (Therapeutic Plasma Exchange) - UC Health

  Aug 29, 2025 — When Is Plasmapheresis Recommended? Doctors recommend plasmapheresis when rapid removal of harmful elements in the blood is necess...

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