Patients taking a dosing regimen larger than 4 mg per day have an
increased potential for dependence. This medication may cause withdrawal
symptoms upon abrupt withdrawal or rapid tapering, which in some cases
have been known to cause seizures. The discontinuation of this
medication may also cause a reaction called rebound anxiety.
Delirium similar to that produced by the tropane alkaloids (gaba antagonists) of Datura (scolopamine and atropine) and seizures have been anecdotally reported in the medical literature from abrupt alprazolam discontinuation.[72][73][74]
Some common symptoms of alprazolam discontinuation include malaise, weakness, insomnia, tachycardia, lightheadedness, and dizziness.[71]
Delirium similar to that produced by the tropane alkaloids (gaba antagonists) of Datura (scolopamine and atropine) and seizures have been anecdotally reported in the medical literature from abrupt alprazolam discontinuation.[72][73][74]
In a 1983 study of patients who had taken long-acting benzodiazepines, e.g., clorazepate,
for extended periods, the medications were stopped abruptly. Only 5% of
patients who had been taking the drug for less than 8 months
demonstrated withdrawal symptoms, but 43% of those who had been taking
them for more than 8 months did. With alprazolam – a short-acting
benzodiazepine – taken for 8 weeks, 35% of patients experienced
significant rebound anxiety. To some degree, these older benzodiazepines are self-tapering.[75]
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